Endocrine Abstracts

Objective: The aim of this meta-analysis is to evaluate the effect of bariatric surgery on sexual function and sex hormone levels in obese patients.Methods: Two independent investigators conducted a literature search of PubMed, Medline and Cochrane databases using the terms bariatric surgery, sexual function and sex hormone to identify appropriate human studies published in English about the effect of bariatric surgery on sexua...

Objective: The purpose of this study was to evaluate the psychometric properties of a novel, patient-reported outcome (PRO) measure, the Hypoparathyroidism (HPT) Symptom Diary (HPT-SD), using data collected during a cross-sectional, noninterventional, observational study. The HPT-SD, developed according to the US Food and Drug Administration PRO guidance, addresses the severity of key symptoms (muscle cramping, tingling and muscle spasms/twitching, fatigue, cognition, emotions...

Background: Antihyperglycermic drugs have been linked to new-onset atrial fibrillation (NAF); however, the effect of different class antihyperglycermic drugs on the development of NAF in elderly patients with diabetes millitus (DM) has not been well studied.Objectives: We investigated the association between different class antihyperglycermic drugs and NAF in elderly patients.Methods: This was a retrospective cohort study performed...

Background: High-resolution magnetic resonance imaging (hrMRI) can assess trabecular bone microarchitecture but the number of image slices required for reliable assessment is unclear.Methods: MRI was performed just below the growth plate of the proximal tibia from 20 healthy controls (all females; median age 21 years (range 18.35) and ten cases (3M:7F; median age 19.5 years (range 16.48) with known bone abnormalities including osteogenesis imperfecta and...

Introduction: Metformin is widely used as oral anti-hyperglycaemic agent to treat type 2 diabetes, with increasing reports of an additional, potential bone protective role.Objective: We investigated the role of AMPK in mediating the effects of metformin on the differentiation of mesenchymal stem cells (MSCs) to either osteoblasts or adipocytes.Methods: Confluent murine MSCs (C3H10T1/2) were treated with metformin (500 μM), a k...

Human plasma contains both cortisol (F) and corticosterone (B). B has been largely neglected in humans as it is 10–20 times less abundant however previous studies suggest B and F have differential tissue-specific actions. Compared with F, B has an enhanced response to ACTH, relatively higher concentrations in brain and CSF and differential transmembrane trafficking by ATP-binding cassette (ABC) transporters. Plasma F is bound to corticosteroid-binding globulin (CBG) and a...

Fractures in diabetic patients are slower to heal and have an increased risk for developing malunion as compared to non-diabetic individuals. Given the known deficiencies in diabetic progenitor cell number and differentiation capacity, it is reasonable to hypothesise the aetiology of diabetic fracture malunion is dysregulated progenitor function. Therefore, we investigated the therapeutic efficacy of locally administered non-diabetic human bone marrow derived mesenchymal stem ...

Introduction: X-linked adrenal hypoplasia congenita (AHC) is a rare developmental disorder of the adrenal cortex. Adrenal insufficiency typically begins in infancy or in childhood. A few individuals present adrenal insufficiency in adulthood.Case report: A 21-year-old man visited our endocrine out-patient clinic due to underdeveloped secondary sexual characteristics, which was found at physical examination for military service. Physical examination revea...

Thyroid cancer is the most prevalent cancer among endocrine malignancies. In clinically, surgical resection combined with radioactive iodine therapy has been proved effective in treating differentiated thyroid cancer, including papillary and follicular thyroid cancers (FTC). However, patients with incurable differentiated thyroid cancer (DTC), poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) exhibit worse prognosis. Therefore, a novel and effecti...

The pathophysiology differs significantly between primary and secondary hyperparathyroidism. Whole exome sequence analysis of parathyroid adenomas showed few somatic variants. The underling mechanisms of the occurrence of sporadic primary hyperparathyroidism remain largely unknown. In this study, we analysed the differences in gene expression between primary and secondary hyperparathyroidism to explore potential functional alterations. Total RNA was extracted from tissues obta...